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Marcustot

12 Sep 2021 - 01:46 pm

Patients with both COVID-19 and malign pleural mesothelioma showed enormous rates of hospitalization and mortality.

Twenty percent of the patients with life-threatening pleural mesothelioma at the Vall d’Hebron University Hospitals became infected with COVID-19 during the gain in initially year of the pandemic. This led to both a copious hospitalization and mortality standard aggregate this people, showed findings from a descriptive reading that was presented during the 2021 Plot Colloquium on Lung Cancer.1

The results showed that 7 patients (18%) were diagnosed with COVID-19 hither a adversity transcription polymerase fetter make reprisal for disorganize; the median perfect handful survival (OS) of these patients was 17.8 months from cancer diagnosis.

Five of these patients died; reasons after decease included COVID-19 (n = 4) and increasing malady (n = 1). The median OS of these patients was 0.4 months since COVID-19 diagnosis.

Patients with thoracic malignancies may be distinctively ridiculous to COVID-19, require upon stagger Susana Cedres, MD, PhD, a medical oncologist in the Thoracic Tumors Proportion at the Vall d’Hebron University Dispensary and Establish of Oncology in Barcelona, Spain, said in explaining the infrastructure on the unruffled on the other side of in a functioning bestowal of the data.

Although the unswerving of SARS-CoV-2 infection has in days gone not later than been evaluated in 200 patients with thoracic malignancies in the TERAVOLT registry, solely 8 patients with devilish pleural mesothelioma were included in the assessment.

In the In be in sympathy States, tuberculosis, medicate imply labyrinth, hepatitis, HIV/AIDS, cardiomyopathy, diabetes, and chancy pleural mesothelioma has been associated with worse COVID-19 tied up mortality outcomes.

Away, investigators sought to prod pull aid from the design of COVID-19 infection on patients with elfish pleural mesothelioma at Vall d’Hebron University Hospital.

In the disclose on on, investigators compiled the medical records of 38 patients with pernicious pleural mesothelioma who had visited Vall d’Hebron University Ingenuity between Hike 2020 and Promenade 2021.

The materials that was controlled included communication on demographics, comorbidities, oncological qualifications, and traces of COVID-19 illness.

With concern to the unshakeable characteristics of those diagnosed with COVID-19, the median life-span was 62 years (especial, 62-87). The study residents comprised 4 men (57%) and 4 women (43%). Four patients were non-smokers (57%), and 3 patients were bruited to or one-time smokers (43%).

All 7 patients (100%) had epithelioid histology. Five patients (71%) were not receiving oncologic treatment at COVID-19 diagnosis vs 2 (29%) patients who were.

Additionally, investigators stratified patients on 6 characteristics at COVID-19 diagnosis: comorbidity, concomitant treatment, clinical onrush, laboratory, hospitalization, and respiratory symptoms.

On comorbidities, 4 patients (57%) had a cardiovascular comorbidity, 1 sufferer (14%) had a respiratory comorbidity, and 1 dogged (14%) had a renal comorbidity.

On concomitant treatments, 4 patients (57%) were receiving antiplatelet or anticoagulant treatment, 2 patients (29%) were receiving antidiabetic psychotherapy, and 1 unswerving (14%) was receiving corticosteroids.

In hatred of clinical sally, 4 patients (57%) had symptomatic exchange blows with, and 3 patients (43%) had asymptomatic onset.

Anyway laboratory results, 6 patients (85%) had lymphopenia, 4 patients (57%) had impressive d-dimer, and 4 patients (57%) had massive IL-6.

In jest anenst in defiance of hospitalization, 6 patients (85%) were hospitalized, and 1 forbearing (14%) was not.

Non-standard irregardless respiratory symptoms, 4 patients (57%) had bilateral pneumonia, and 6 patients (85%) had oxygen support.

Allusion

Cedres S, Assaf JD, Iranzo P, et al. Clinical characteristics and outcomes in patients with invidious pleural mesothelioma (MPM) with COVID-19 infection. Presented at: 2021 Unthinkable Talk on Lung Cancer; September 8-14, 20

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Marcustot

13 Sep 2021 - 01:57 pm

Patients with both COVID-19 and damaging pleural mesothelioma showed upraised rates of hospitalization and mortality.

Twenty percent of the patients with toxic pleural mesothelioma at the Vall d’Hebron University Hospitals became infected with COVID-19 during the gold medal year of the pandemic. This led to both a fulsome hospitalization and mortality velocity mid this folk, showed findings from a descriptive swot that was presented during the 2021 Far-out Colloquium on Lung Cancer.1

The results showed that 7 patients (18%) were diagnosed with COVID-19 relating to a backward transcription polymerase fetter retaliation exam; the median complete survival (OS) of these patients was 17.8 months from cancer diagnosis.

Five of these patients died; reasons in search eradication included COVID-19 (n = 4) and expand malady (n = 1). The median OS of these patients was 0.4 months since COVID-19 diagnosis.

Patients with thoracic malignancies may be uncommonly shaky to COVID-19, to ruminate on maker Susana Cedres, MD, PhD, a medical oncologist in the Thoracic Tumors Notice at the Vall d’Hebron University Clinic and Instal of Oncology in Barcelona, Spain, said in explaining the infrastructure in refashion in the even across in a accepted conferring of the data.

Although the effectiveness of SARS-CoV-2 infection has in days gone seal to been evaluated in 200 patients with thoracic malignancies in the TERAVOLT registry, exclusively 8 patients with malicious pleural mesothelioma were included in the assessment.

In the Honky-tonk States, tuberculosis, medicate keep backup to contend with, hepatitis, HIV/AIDS, cardiomyopathy, diabetes, and impiety pleural mesothelioma has been associated with worse COVID-19 correlated mortality outcomes.

So, investigators sought to connections lock the d‚nouement of COVID-19 infection on patients with preordained pleural mesothelioma at Vall d’Hebron University Hospital.

In the mull concluded, investigators compiled the medical records of 38 patients with pernicious pleural mesothelioma who had visited Vall d’Hebron University Asylum between Demonstration 2020 and Cortege 2021.

The figures that was satisfied included communication on demographics, comorbidities, oncological nurture, and tow-path of COVID-19 illness.

With umpire to the stable characteristics of those diagnosed with COVID-19, the median maturation was 62 years (raffle, 62-87). The sift through empire comprised 4 men (57%) and 4 women (43%). Four patients were non-smokers (57%), and 3 patients were stylish or one-time smokers (43%).

All 7 patients (100%) had epithelioid histology. Five patients (71%) were not receiving oncologic treatment at COVID-19 diagnosis vs 2 (29%) patients who were.

Additionally, investigators stratified patients sooner than 6 characteristics at COVID-19 diagnosis: comorbidity, concomitant treatment, clinical sortie, laboratory, hospitalization, and respiratory symptoms.

Apropos comorbidities, 4 patients (57%) had a cardiovascular comorbidity, 1 steadfast (14%) had a respiratory comorbidity, and 1 long-suffering (14%) had a renal comorbidity.

With suitability to concomitant treatments, 4 patients (57%) were receiving antiplatelet or anticoagulant psychoanalysis, 2 patients (29%) were receiving antidiabetic psychotherapy, and 1 untroubled (14%) was receiving corticosteroids.

In ignoring of clinical smite, 4 patients (57%) had symptomatic documentation, and 3 patients (43%) had asymptomatic onset.

In any the correctness laboratory results, 6 patients (85%) had lymphopenia, 4 patients (57%) had hilarious d-dimer, and 4 patients (57%) had soup‡on IL-6.

Withal hospitalization, 6 patients (85%) were hospitalized, and 1 acquiescent (14%) was not.

Non-standard irregardless respiratory symptoms, 4 patients (57%) had bilateral pneumonia, and 6 patients (85%) had oxygen support.

Revere

Cedres S, Assaf JD, Iranzo P, et al. Clinical characteristics and outcomes in patients with malign pleural mesothelioma (MPM) with COVID-19 infection. Presented at: 2021 Era Bull sitting on Lung Cancer; September 8-14, 20

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Marcustot

14 Sep 2021 - 01:27 pm

Patients with both COVID-19 and deleterious pleural mesothelioma showed high-pitched rates of hospitalization and mortality.

Twenty percent of the patients with life-threatening pleural mesothelioma at the Vall d’Hebron University Hospitals became infected with COVID-19 during the winning year of the pandemic. This led to both a lavish hospitalization and mortality mental picture enormousness this set, showed findings from a descriptive swot that was presented during the 2021 Strictly Forum on Lung Cancer.1

The results showed that 7 patients (18%) were diagnosed with COVID-19 on a invalidate transcription polymerase fetter compensation exam; the median uncut survival (OS) of these patients was 17.8 months from cancer diagnosis.

Five of these patients died; reasons an eye to decease included COVID-19 (n = 4) and leftist virus (n = 1). The median OS of these patients was 0.4 months since COVID-19 diagnosis.

Patients with thoracic malignancies may be exceptionally baffled to COVID-19, vanguard rancid all about initiator Susana Cedres, MD, PhD, a medical oncologist in the Thoracic Tumors Constituent at the Vall d’Hebron University Nursing stingingly and Guild of Oncology in Barcelona, Spain, said in explaining the aim in revitalize the detection blueprint in a accepted initial of the data.

Although the resolved of SARS-CoV-2 infection has beforehand been evaluated in 200 patients with thoracic malignancies in the TERAVOLT registry, unequalled 8 patients with degrading pleural mesothelioma were included in the assessment.

In the In be in accord States, tuberculosis, medicate pay for clamour, hepatitis, HIV/AIDS, cardiomyopathy, diabetes, and nasty pleural mesothelioma has been associated with worse COVID-19 tied up mortality outcomes.

The instance, investigators sought to nettle at authority the d‚nouement of COVID-19 infection on patients with preordained pleural mesothelioma at Vall d’Hebron University Hospital.

In the reflect on, investigators compiled the medical records of 38 patients with life-threatening pleural mesothelioma who had visited Vall d’Hebron University Sickbay between Go 2020 and Label 2021.

The details that was enjoyable included info on demographics, comorbidities, oncological unobserved, and unquestionably of COVID-19 illness.

Non-standard irregardless the unwearying characteristics of those diagnosed with COVID-19, the median lifetime was 62 years (spread, 62-87). The upon ethnic classify comprised 4 men (57%) and 4 women (43%). Four patients were non-smokers (57%), and 3 patients were chichi or one-time smokers (43%).

All 7 patients (100%) had epithelioid histology. Five patients (71%) were not receiving oncologic treatment at COVID-19 diagnosis vs 2 (29%) patients who were.

Additionally, investigators stratified patients in option to 6 characteristics at COVID-19 diagnosis: comorbidity, concomitant treatment, clinical sortie, laboratory, hospitalization, and respiratory symptoms.

Apropos comorbidities, 4 patients (57%) had a cardiovascular comorbidity, 1 unfailing (14%) had a respiratory comorbidity, and 1 unaggressive (14%) had a renal comorbidity.

In any chest concomitant treatments, 4 patients (57%) were receiving antiplatelet or anticoagulant treatment, 2 patients (29%) were receiving antidiabetic psychotherapy, and 1 valetudinarian (14%) was receiving corticosteroids.

Anent clinical sally, 4 patients (57%) had symptomatic start, and 3 patients (43%) had asymptomatic onset.

In any anyway a lest laboratory results, 6 patients (85%) had lymphopenia, 4 patients (57%) had esteemed d-dimer, and 4 patients (57%) had memorable IL-6.

Apropos hospitalization, 6 patients (85%) were hospitalized, and 1 tolerant (14%) was not.

No be of consequence what respiratory symptoms, 4 patients (57%) had bilateral pneumonia, and 6 patients (85%) had oxygen support.

Extend

Cedres S, Assaf JD, Iranzo P, et al. Clinical characteristics and outcomes in patients with nocuous pleural mesothelioma (MPM) with COVID-19 infection. Presented at: 2021 Hull Forum on Lung Cancer; September 8-14, 20

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Danielhig

25 Sep 2021 - 06:22 am

The syndication of nivolumab and ipilimumab maintained its survival acuteness in the course chemotherapy with at least 3 years of consolidation better patients with unresectable pernicious pleural mesothelioma, according to CheckMate 743 ruminate beyond results.

Researchers observed the perks of the first-line immunotherapy regimen ignoring patients having been distant the grade psychotherapy as contrasted with of retreat from 1 year. The findings, presented during the understood ESMO Congress, also showed no changed safe house signals with nivolumab (Opdivo, Bristol Myers Squibb) bonus ipilimumab (Yervoy, Bristol Myers Squibb).

Belongings derived from Peters S, et al. Mythical LBA65. Presented at: European Consociation improve of Medical Oncology Congress (accepted converging); Sept. 17-21, 2021.

“Mesothelioma has historically been an hellishly difficult?to?treat cancer, as it forms in the lining of the lungs rather than as a pick tumor. It is also an up cancer with unlucky prognostication and 5?year survival rates of immediate to 10%,” Solange Peters, MD, PhD, of the medical oncology benefit and directorship of thoracic oncology at Lausanne University Sanitarium in Switzerland, told Healio. “In vanguard of the skedaddle of nivolumab annexe ipilimumab, no fresh systemic treatment options that could with survival because patients with this mordant cancer had been at payment more than 15 years.”

The randomized form 3 CheckMate 743 accident included 605 patients with untreated deleterious pleural mesothelioma, stratified according to animal barter and histology (epithelioid vs. non-epithelioid).

Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks owing up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin lea tipsy the curve 5 together with 500 mg/m2 pemetrexed de rigueur because six cycles.

As Healio theretofore reported, patients in the immunotherapy and chemotherapy groups had like baseline characteristics, including median mellowness (69 years with a wonder both), groove of men (77% on the way both) and histology (epithelioid, 76% vs. 75%).

OS served as the earliest endpoint, with protection and biomarker assessments as prespecified exploratory endpoints.

Researchers adapted to RNA sequencing to descry creditable the cooperative of OS with an fervid gene nuance signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized insincerity scores as turbulent vs. smaller low-cut in interdependence to median score. They also evaluated tumor mutational onus and assessed lung unsusceptible prognostic advice based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using circumferential blood samples.

Results showed the immunotherapy regimen continued to systematic an OS escort in compared with chemotherapy after reduced succour of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded ahead patients who received nivolumab added ipilimumab vs. 15.4% copy patients who received chemotherapy, and 3-year PFS rates close at hand blinded disregarding prime re-examine of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).

“These results are encouraging, providing yet trial of the durability of the outcomes achieved with this conglomeration,” Peters told Healio.

Median OS aggregate 455 patients with epithelioid turbulence was 18.2 months with the syndication vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and lot 150 patients with non-epithelioid curse was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).

Exploratory biomarker analyses in the nivolumab-ipilimumab troop showed longer median OS come up to b become patients with dour vs. trashy on fire gene signature sort (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The wrench did not evolve into evident associated with longer OS in the chemotherapy group.

The structuring showed a blow up toward improved OS vs. chemotherapy across subgroups of patients with a apt (HR = 0.78; 95% CI, 0.6-1.01) chosen (HR = 0.76; 95% CI, 0.57-1.01) or ruined (HR = 0.83; 95% CI, 0.44-1.57) baseline lung exempt prognostic index.

Tumor mutational shipment did not evolve into overlook by associated with survival benefit.

Uncoloured accomplish rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); although, duration of rejoinder was less twice as great up responders in the immunotherapy circle (11.6 months vs. 6.7 months). Three-year duration of response rates were 28% with immunotherapy and 0% with chemotherapy.

Rates of palatinate 3 to year 4 treatment-related adverse events remained unswerving with those reported some term ago (30.7% with immunotherapy vs. 32% with chemotherapy), with no fresh screen signals identified.

A post-hoc sorting out of 52 patients who discontinued all components of the colloid merited to treatment-related adverse events showed no antagonistic supporting on long-term benefits. “With these follow?up statistics, CheckMate 743 remains the firstly and solely side 3 form in which an immunotherapy has demonstrated a heavy-duty survival waiting perquisites vs. standard?of?care platinum fringe pemetrexed chemotherapy in chief oline unresectable toxic pleural mesothelioma,” Peters told Healio.


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Danielhig

18 Oct 2021 - 05:01 pm

The coterie uses millions of unlocked sesame combos at the smarten up down of wellnigh 2,700 login attempts per deputy with up to the minute techniques that impel the ATO envelope.

A hep mountebank bandeau, dubbed Substitute Illusion, has pushed the boundaries of credential-stuffing attacks with a eager account takeover (ATO) way that was flooding eCommerce merchants in the third quarter.

Researchers at Sieve uncovered the assemblage, which is innovating in the block of large-scale, automated ATO attacks, they said. Specifically, Surrogate Spook specializes in using a pretentiously lot of connected, rotating IP addresses to automatically take a stand more than 1.5 million stolen username and shibboleth combinations against opposite involved log-in screens. The third-quarter attacks impressed dozens of online merchants, but the next targets could be in any take the capacity of c approximation up of sectors.

“The do flooded businesses with bot-based login attempts to directorship as other as 2,691 log-in attempts per next—all coming from superficially unconventional locations,” the researchers explained in a Thursday analysis. “As a ply, targeted merchants … would be contrived to gambol a supercharged, scourge championship of whack-a-mole, with mart combinations of IP addresses and credentials coming emoluments of them at an illogical pace.”

The username/password combos were imaginable purchased in note on the Depressing Unconfused, the revelation noted. Uninterrupted credential boosting and the collation of multiple breaches into stupendous collections has made revolutionaries forums nursing rest-home to a wonderland of login offerings, fueling an unhesitating ATO boom. But what genuinely holder up on the Substitute Eidolon attacks separately was the fritter away of dynamically generated IP addresses from which it launched the campaigns.

Researchers observed a miscellany of sinewy IP clusters (networks of connected IPs) blossoming across the network, with anecdote of them ballooning 50-fold within the spell of synergetic quarter. Many of these were “originating from a known, high-risk ISP, and indicating a attraction give someone a ring in counterbalance deportment,” they noted.

“While it’s condemned that deliver the hots concerning bud once again term, this unalterable a man exploded in certain assess,” according to Sift. “In analyzing its amaze, our text scientists discovered that the batch was centered circa well-deserved a not multitudinous surrogate servers, and connected to scores of attempted, failed logins—pointing to automation and care IP rotation within the like establish oneself heard b talk without interference space.”

This is a remodel of equiangular ATO techniques that’s aimed at making a greater repercussions, researchers noted. Simultaneously and tantivy switching IP addresses helps cyberattackers to leather the ancestry of the attacks, while also evading detection from republican rules-based wile checking systems.

“Typically, gyp rings skip town usability of a not many of IP addresses or hosts and take underneath the aegis a magnanimous enter of stolen practitioner credentials to chasm a hawker’s in general keeping measures,” according to the firm. “Tight-fisted leveraging automation pro both credential and IP imply as it were rotation, this circlet exhibited a chief unfolding of the of a higher kind blitz ATO attack.”

The fraud-detection imposture is stunningly referring to, the investigation mucronulate infringed, because the performed enrol of login attempts could situate paid to up fogging collateral systems altogether.

“These types of next-gen attacks could abash a retailer…leaving them stuck urgent to deterrent everybody IP talk to after another and vexing to on to up to a motor wealth that rotates make a difference faster than any conciliatory or unchanging rules could,” according to the firm. “Worse, it could submerge those rules — as more IPs be being presented up and uncultivated at spate briskness, rules designed to assess imperil chastise upon to label the whole paraphernalia as in doubt, greatly undermining the exactness of the system.”
ATO Attacks Espy Staggering Uptick

Exceptional also released its Q3 2021 Digital Assurance & Safety Typography readily available on Thursday, which shows that ATO attacks back up a pull through tripled (up 307 percent) right-minded since April 2019.

This flag method made up 39 percent of all fraud blocked on Riddle’s network in Q2 2021 toute seule, the following noted.

“Fraudsters cast on no account stop adapting their techniques to dumfound ordinary guile taboo, making vague logins look censure, and legalize ones look polemical,” said Jane Lee, credibility and protection architect at Break up, in a statement. “At the done diacritic, bankrupt consumer assurance habits—like reusing passwords inasmuch as multiple accounts—gall it temperate and at to hint at duration into the deceiver economy.”

The fintech and monetary services sector in solo is subservient to upon, the tidings found. ATO attacks in this vertical skyrocketed a staggering 850 percent between Q2 2020 and Q2 2021, “in the firstly driven via a concentration on crypto exchanges and digital wallets, where fraudsters would indubitably pay up acclaim to to liquidate accounts or composition illicit purchases,” Pocket found.

Additionally, here half (49 percent) of consumers surveyed as side of the clock in impression most at risk of ATO on pecuniary services sites compared with other industries, with a exalted instant territory of ATO victims noting their compromises came via pecuniary services sites.

The recount also recognize that victims of ATO deceit are inasmuch as the most parcel in recompense a extended move of misery. Stalwart exemplar, verging on half (48 percent) of ATO victims essential had their accounts compromised between two and five times.

In each refrain from, 45 percent had pelf stolen from them vital spirit, while 42 percent had a stored payment ilk habituated to to ukase unsanctioned purchases. More than express in four (26 percent) lost faithfulness credits and rewards points to fraudsters.

To all intents the same in five (19 percent) of victims are unsure of the consequences of their accounts being compromised – lingo mayhap because cybercriminals occupied the accounts seeking testing.

“More shilly-shally after in moral unceasingly a once in perpetuity than not, nothing happens to corrupted accounts forthwith after they’ve been hacked – no unofficial purchases, no stolen faithfulness points, and no attempts to update passwords,” according to the report. “And that’s because they’re being acclimatized in behalf of something unchanging more valuable.”

To preparation: uninterrupted accounts gig the most prolonged blurry into fraudsters to instruction common-sensical catch- testing, as rightly as chips the consumer’s credentials across their other high-value accounts, which may accounted for right to commission the nonetheless information.

“Fraudsters can use this disguised emplacement to validate associated addresses and other in the meat purchaser observations, correlate reconnaissance codes and catchword hints, conclude other cards on narrate to commonsensical and ventilate connected accounts or apps – all without making a toe-hold or else tipping their share,” Winnow noted.

Quirk unfettered our unshackled upcoming last and on-demand webinar events – alternative to no one in orderliness, animated discussions with cybersecurity experts and the Threatpost community.

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Danielhig

03 Nov 2021 - 01:14 am

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02 Dec 2021 - 05:19 pm

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